Tuesday, June 19, 2018

Treatment of ACE Inhibitor‐Induced Cough



ACE inhibitors are recommended for treatment of patients with hypertension, proteinuria due to chronic kidney disease, and heart failure. However, therapy with ACE inhibitors is commonly associated with a dry, hacking cough, which results in discontinuation in 4% to 20% of patients

If the ACE inhibitor cannot be tolerated and the goal of therapy is to block the renin-angiotensin system, substitution with an ARB should be considered.

Practice guidelines published by the American College of Chest Physicians in 2006 recommend that if discontinuation of an ACE inhibitor is not an option and the medication cannot be replaced with an ARB, other medications may improve an ACE-inhibitor–induced cough. These medications include inhaled cromolyn, theophylline, the NSAIDs sulindac and indomethacin, the calcium channel blockers amlodipine and nifedipine, and ferrous sulfate. Additionally, a repeat trial of another ACE inhibitor may be attempted.





Reference:

https://mospace.umsystem.edu/xmlui/bitstream/handle/10355/7839/WhatTreatmentACEInhibitorCough.pdf?sequence=1

من التفاعلات الدوائية : أستيل سيستايين N-Acetyl Cysteine مع Vasodialators

N-acetylcysteine NO يزيد إنتاج و Vasodialators (زي مركبات نتيروجلسرين) تخضع في جسمنا لعملية (تحوّل حيوي BIOTRANSFORAMTION) لكي يتكون مركب...